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	Provedor de dados BJMBR (2) Anais da ABC (AABC) (1) Autor AKPINAR,EROL (1) Abreu,G.R. (1) BAYIR,YASIN (1) CADIRCI,ELIF (1) CALIK,ILKNUR (1) Claudio,E.R.G. (1) DIYARBAKIR,BUSRA (1) Gouvea,S.A. (1) Guo,Dongmei (1) HALICI,ZEKAI (1) Liu,Han (1) Mauad,H. (1) Mengal,V. (1) Santuzzi,C.H. (1) Tiradentes,R.V. (1) UN,HARUN (1) Zhao,Zhengbo (1) Mais... Palavra-chave Aliskiren (3) 2K1C hypertension (1) Apoptosis (1) Cardiac hypertrophy (1) Cytokines (1) Endothelial dysfunction (1) Fibrosis (1) L-arginine (1) Lung injury (1) Mammalian target of rapamycin (1) Oxidative stress (1) Pleurisy (1) RAAS and oxidative stress (1) Rat (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2019 (1) 2015 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways BJMBR Zhao,Zhengbo; Liu,Han; Guo,Dongmei. Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) and apoptosis signaling using in vivo and in vitro models of cardiac hypertrophy. A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1. The expression of hypertrophic, fibrotic, and apoptotic markers was determined by RT-qPCR. The protein expression of apoptotic markers mTOR and p-mTOR was assessed by western blot analysis. The proliferation of H9C2 cells... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aliskiren; Cardiac hypertrophy; Fibrosis; Mammalian target of rapamycin; Apoptosis. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000200602 Combined aliskiren and L-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension BJMBR Santuzzi,C.H.; Tiradentes,R.V.; Mengal,V.; Claudio,E.R.G.; Mauad,H.; Gouvea,S.A.; Abreu,G.R.. Angiotensin II is a key player in the pathogenesis of renovascular hypertension, a condition associated with endothelial dysfunction. We investigated aliskiren (ALSK) and L-arginine treatment both alone and in combination on blood pressure (BP), and vascular reactivity in aortic rings. Hypertension was induced in 40 male Wistar rats by clipping the left renal artery. Animals were divided into Sham, 2-kidney, 1-clip (2K1C) hypertension, 2K1C+ALSK (ALSK), 2K1C+L-arginine (L-arg), and 2K1C+ALSK+L-arginine (ALSK+L-arg) treatment groups. For 4 weeks, BP was monitored and endothelium-dependent and independent vasoconstriction and relaxation were assessed in aortic rings. ALSK+L-arg reduced BP and the contractile response to phenylephrine and improved... Tipo: Info:eu-repo/semantics/article Palavras-chave: 2K1C hypertension; Endothelial dysfunction; Aliskiren; L-arginine; RAAS and oxidative stress. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100065 Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats Anais da ABC (AABC) BAYIR,YASIN; UN,HARUN; CADIRCI,ELIF; AKPINAR,EROL; DIYARBAKIR,BUSRA; CALIK,ILKNUR; HALICI,ZEKAI. Abstract Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues were collected and biochemical, molecular and pathological examinations were performed. In our study, pleural inflammation decreased superoxide dismutase activity and the glutathione level and increased the malondialdehyde level in the lung of rats, while Aliskiren increased the superoxide dismutase activity and glutathione level and decreased the malondialdehyde level. In addition,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aliskiren; Cytokines; Lung injury; Oxidative stress; Pleurisy; Rat. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100801 Registros recuperados: 3 Primeira ... 1 ... Última

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